Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs


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Ovelar Ferrero, C. Garatea Aznar 1 , A. Ovelar Ferrero 1 , N. Tirapu Tapiz 1 , R. Monreal 1 , J. Zabalza 1 , M. Browse posters. Brought to you by.

International Collaboration on Cancer Reporting

This poster is published under an open license. Please read the disclaimer for further details. Tirapu Tapiz, A. Ovelar Ferrero, R. US images show various simple renal cyst on the left kidney and a hypoechoic exophytic lesion that suggested solid tumor vs complex cyst given its echogenicity. A multiphase CT study was hence performed. The lesion showed aparent enhancement after contrast administration and it was reported as posible hypovascular renal tumor.

MR images demonstrated the cystic nature of the lesion.

Note the angular interphase of the lesion with adjacent cortex, a finding associated to benign lesions. US images show various simple renal cyst on Learning objectives 1 To review the US, CT and MR imaging features of papillary renal cell carcinoma 2 To emphasize the key points in the differential diagnosis with other tumors 3 To illustrate this review with some cases studied in our institution.

Clin Cancer Res. Incidence, clinicopathological features and fusion transcript landscape of translocation renal cell carcinomas. Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein.

J Pathol. Cancer Res. Renal cell carcinoma with TFE3 translocation and succinate dehydrogenase B mutation. Mod Pathol. Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assay. Argani P, Ladanyi M. Renal carcinomas associated with Xp World Health Organization Classification of Tumours.

The t X;1 p Hum Mol Genet. A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t 6;11 p Current insights into long non-coding RNAs in renal cell carcinoma. Int J Mol Sci. Genome Res. LncRNA, NEAT1 is a prognosis biomarker and regulates cancer progression via epithelial-mesenchymal transition in clear cell renal cell carcinoma. Cancer Biomark. Nat Struct Mol Biol. Cloning of an Alpha-TFEB fusion in renal tumors harboring the t 6;11 p21; q13 chromosome translocation.

Who Classification Of Tumours Of The Urinary System And Male Genital

Alpha gene upregulates TFEB expression in renal cell carcinoma with t 6;11 translocation, which promotes cell canceration. Int J Oncol. The translocation t 8;16 p11; p13 of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Results: Bladder recurrence developed in 38 patients Among these, 25 patients with HG upper tract urothelial carcinoma HG bladder recurrence developed in 24 patients Stages pTa, pT1, pT2, or higher bladder recurrence developed in 26 On uni- and multivariate analyses, the risk of bladder recurrence was independent of any clinicopathologic characteristics.

Conclusion: High rate and short time interval of bladder recurrence after NU were found, with no specific subgroup of patients with increased risk. These findings support prescribing adjuvant intravesical therapy to all patients after NU.

Keywords: urothelial upper tract tumors, bladder recurrence, nephroureterectomy. Urothelial carcinoma UC is the fourth most common solid malignancy and the eighth most fatal malignancy in men.

Transitional cell carcinoma

UCs are notorious for their high recurrence rate. The field cancerization theory suggests that multiplicity is due to carcinogenic exposure of the entire urothelium. In this study, we estimated the rate of bladder recurrence following NU in an attempt to identify subgroups that are at a higher risk for this type of recurrence. Surgery was done either openly or laparoscopically. In either way, a bladder cuff was removed.

Physiology of Micturition

Tumors were staged according to the tumor node metastasis TNM classification 17 and graded according to the World Health Organization classification. Follow-up was based on tumor grade. In patients with high-grade tumors, cystoscopy and urinary cytologic examination were done at 3-month intervals in the first year, at 6-month intervals for another 2 years, and annually for an additional 2 years. Annual ultrasonic examination of the urinary system was then done indefinitely. Computed tomography scan was performed at 6-month intervals for the first 3 years. For low-grade tumor, the same protocol was applied without computed tomography or cytology.

Additional investigations were performed if clinically indicated. Patients included in the study were followed for at least 6 months or until disease recurrence or death. Median follow-up was 72 months range 6— months.

INTRODUCTION

Data for all patients were available and none were lost to follow-up. Disease-free and overall survival rates were calculated from the day of NU. The effect of the following parameters on recurrence and survival was assessed: age, gender, UTUC grade, stage, previous bladder UC, location in the urinary system, type of surgery laparoscopic vs. Vesical and extravesical tumor recurrences were analyzed separately. Statistical analysis was performed using SPSS v The official institutional review committee which approved our study is the Ethics Helsinki Committee at Hadassah University Hospital for the conduct of clinical studies.

All data were kept secured with the relevant precautions. Committee approval number: HMO Patient consent was not required. UTUC was located in the renal pelvis in 52 patients Tumor stages were pTa and pT1 in 22 Sixty-three patients Twelve patients Thirty-seven patients Surgery was laparoscopic in 43 patients Ureteral margins were negative in all patients.

During follow-up, 51 patients Among them, 38 In 20 patients Overall survival rate at 5 years was High-grade tumor and advanced age were associated with lower survival rates with an odds ratio of 0.

WHO Tumours of the Urinary and Male Genital Organs

However, stage, previous ureteroscopy, gender, location, history of previous bladder cancer, and surgical approach showed no significant effect on overall survival. Disease-specific survival rate was Bladder recurrence occurred in 38 patients

Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs

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